![]() However, there are few studies and limited data on the nutritional intervention of children with CP currently. ![]() Another retrospective study suggested that a high-calorie formula (1.0 kcal/ml) could help the infants in the intensive care unit gain weight ( 9). A randomized controlled trial showed that feeding the protein and energy-enriched formula promoted more adequate nutrient intake and facilitated energy and nitrogen balance in infants with a critical illness ( 8). Therefore, it is essential that undernutrition in this group of children is recognized promptly and treated appropriately to prevent secondary bad outcomes.Įnteral nutrition is the preferred way to meet children's energy and nutrient requirements ( 7). Furthermore, cognitive and motor development may be affected when children are combined with chronic undernutrition ( 6). Except for the failure to thrive, decreased muscle strength, an impaired immune system, and an increased risk of infection may occur in undernourished children. One of the main reasons is inadequate intake because of eating and drinking dysfunction ( 5). There are many reasons for undernutrition in children with CP, e.g., diarrhea, increased muscle tone, and the presence of involuntary movements. Children with CP often suffer from dysphagia, feeding difficulty, gastroesophageal reflux, slow gastric emptying, and digestion, which usually result in undernutrition and growth failure ( 4). According to published studies, about 22.2–76.6% of children with CP are undernourished ( 2, 3). In addition to motor impairment, undernutrition is a prominent comorbidity in children with CP. Ĭonclusion: Nutritional intervention with a high-calorie formula may be an effective and safe option in children with CP for improving undernutrition and gross motor dysfunction.Ĭlinical trial registration: identifier: ChiCTR2000033878.Ĭerebral palsy (CP) is an early-onset, non-progressive neuromotor disorder of the brain in children with multiple neurological deficits and a complex molecular etiology ( 1). During the study period, 16 children experienced at least one mild adverse event. There were significant differences in changes in weight, weight-for-age z-scores, and GMFM between the two groups ( p < 0.05). After 6 months of treatment, the weight, height, z-scores (weight-for-height, weight-for-age, and BMI-for-age), and GMFM of both groups were significantly improved ( p < 0.05). Results: From July 2020 to December 2021, a total of 119 participants were enrolled and randomized, and 110 participants completed the study (with 54 children in the high-calorie formula group and 56 children in the control group). In addition, the effective rate of nutritional intervention, and adverse events were simultaneously assessed. We compared the nutritional status and gross motor function of participants in both groups based on weight, height, z-scores (weight-for-age, height-for-age, weight-for-height, and BMI-for-age), and the Gross Motor Function Measure (GMFM), respectively, at baseline, 3-, and 6-months follow-up. Indirect calorimetry was used to estimate energy requirements. ![]() Participants were randomly allocated (1:1) to a high-calorie formula group or a Chinese daily food diet group (control group) for 6 months. Methods: In this prospective, assessor-blind, and randomized controlled trial, we recruited children (1–10 years) with CP and undernutrition based on the WHO and the American Society for Parenteral and Enteral Nutrition criteria from the National Children's Medical Center. Chinese daily food on the nutritional status and motor function of undernourished children with cerebral palsy (CP).
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